Opportunities
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Project: Development of broad-spectrum host-targeting antivirals against coronaviruses.
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Start date: 1 Jan 2025
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About the project: Viruses manipulate host pathways upon infection, activating cellular signalling pathways leading to changes in host cell protein phosphorylation. Kinases that regulate these pathways have been suggested to be important antiviral drug targets. We have identified several kinase-targeting proteolysis targeting chimera (PROTAC) molecules that have anti-coronavirus activity. This project aims to take this further, to develop these PROTACs as pan-coronavirus inhibitors and investigate their mechanism of action using a combination of molecular biology and cell biology techniques. This project provides a unique opportunity to work at the forefront of virology research, making important contributions towards understanding the fundamental aspects of coronaviruses, as well as having a positive impact on public health measures for infection control.
More information about the project can be found here.
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Funding: Fully-funded for UK students. Includes stipend at the UKRI rate (currently £19,237/year).
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Deadline: 26 July 2024
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How to apply: Please visit the DMU Scholarship website for information on how to apply.
Virology Lab Associate position is available via the DMU Graduate Champions Internship Scheme. This paid internship will give the successful candidate an opportunity to support on-going research in the lab.
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6 week period, from 19 Aug to 27 Sep
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18.5 hours per week, with a pay rate of £11.44 per hour
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DMU alumni who completed their undergraduate degree in 2023 are eligible to apply
For more details about the application process, or to apply: contact champions@dmu.ac.uk