Project: Development of broad-spectrum host-targeting antivirals against coronaviruses.
Start date: 1 Jan 2025
About the project: Viruses manipulate host pathways upon infection, activating cellular signalling pathways leading to changes in host cell protein phosphorylation. Kinases that regulate these pathways have been suggested to be important antiviral drug targets. We have identified several kinase-targeting proteolysis targeting chimera (PROTAC) molecules that have anti-coronavirus activity. This project aims to take this further, to develop these PROTACs as pan-coronavirus inhibitors and investigate their mechanism of action using a combination of molecular biology and cell biology techniques. This project provides a unique opportunity to work at the forefront of virology research, making important contributions towards understanding the fundamental aspects of coronaviruses, as well as having a positive impact on public health measures for infection control.
More information about the project can be found here.
Funding: Fully-funded for UK students. Includes stipend at the UKRI rate (currently £19,237/year).
Eligibility: Applicants must:
Possess a UK Honours degree in Biochemistry, Biomedical Sciences or related fields with at least an upper second class (or overseas equivalent), a Masters Degree in similar fields, or an academic or professional qualification plus experience in their sector or industry.
Be enthusiastic about the research topic.
Demonstrate the ability to clearly communicate complex ideas to a variety of audiences.
Be self-motivated and able to work independently and with a team.
Demonstrate competence in the use of the English language. Please see section 5b here for further details on meeting our English language entry criteria.
How to apply:
Please send the following documents to PGRscholarships@dmu.ac.uk:
A completed DMU Scholarship Application Form
A 2-page CV
Please see the DMU Scholarship website for more details on the application process.
Deadline: 26 July 2024
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